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- Gut microbiota-derived metabolites are key molecular mediators between the microbiota and host.
- Several untargeted studies have demonstrated broad disturbances of the gut metabolome in IBD, which is in keeping with the known dysbiosis in gut bacterial communities.
- Metabolite groups of interest include short-chain fatty acids, bile acid metabolites and tryptophan metabolites, with essential roles for these in normal immune development, homeostasis and IBD.
- Multinational, longitudinal cohorts, sampling and analysis standardization and model systems will be required to expand our knowledge of these associations.
- Such approaches show promise for identifying new host targets and the microbial tools with which to target them. READ MORE HERE.